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B cells lacking c-Rel show increased sensitivity to B-cell receptor-mediated apoptotic signals [ 96]. c-Rel is indispensable for expression of IL-12 and IL-23 subunits in mouse dendritic cells [ 97, 98].
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No significant difference was seen between four groups in eNOS expression (Fig. 4A), nor in eNOS dimerization, which is indispensable for the expression of its enzymatic activity (Fig. 4B).
Wild-type MLL1 has also been shown to be indispensable for HOXA9 expression in leukemia cells [5].
We also detected one contradiction about JKD function, which we predict is not indispensable for SCR expression or function.
Although Mef2c and Mef2d proteins are not required for muscle fibre terminal differentiation, they are indispensable for myofilament expression and myofibril assembly in zebrafish fast muscle fibres [ 49].
Genes in the sulfate assimilation pathway are regulated coordinately and MET4 is indispensable for their expression (Thomas and Surdin-Kerjan 1997).
The interaction of Runx3 and FOXO3 is indispensable for Bim expression and apoptosis in mouse embryonic fibroblasts and gastric cancer cells [ 54].
These results suggest that the three pathways were indispensable for the expression of SBD-1 by E2 in ovine oviduct epithelial cells.
In this study, we report that type I IFN signaling is indispensable for the expression of IFN- α, IFN- β, cGAS, and TLR9in the draining lymph nodes (DLNs) in the early stage following i.m.
Moreover, recent data have shown that CdtB is the main component and indispensable for the expression of CDT holotoxin activity [ 6, 8], and the sequence of cdtB was also highly conserved among A.actinomycetemcomitans species [ 21].
IFIH1 functions as cytosolic receptor that leads to the selective activation of type I IFN genes and is indispensable for sustained expression of IFN in response to paramyxovirus infection [ 41, 42].
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Justyna Jupowicz-Kozak
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