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Hence, an animal model is indispensable for demonstrating the benefit of any new modality sufficiently different from the standard treatment.
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Furthermore, we map the position of PKD within the autophagic network to Vps34, a lipid kinase whose function is indispensable for autophagy, and demonstrate that PKD is found in the same molecular complex with Vps34.
Interestingly, Ago2 catalytic activity is indispensable for Rad51 focus formation and HR, demonstrating that diRNAs most likely needs to be in a single-strand configuration to support Rad51 accumulation and subsequent repair.
These data build upon previous work from Sandalova and colleagues by demonstrating that BIM is indispensable for maximum sensitivity to restimulation-induced apoptosis of human T cells.
Figure 5G shows that the sTRAIL FeSOD-induced apoptosTRAIL FeSOD-inducedined in the hypertonic medium, demonstrapoptosisOdrasticallyispensable for sTRAIL:FeSOdeclinedd apoptosin.
Together, these findings demonstrate that CIC is indispensable for suppression of lymphoproliferative autoimmunity.
Here, we demonstrate that BCL11A is indispensable for normal HSC function.
This observation demonstrates that ATF3 is indispensable for TLR4-mediated NF-κB and JNK activation.
Furthermore, our results demonstrate that Math6 is indispensable for early embryonic development and indicate a more widespread function for this factor in tissue-specific differentiation processes that are dependent on class II bHLH genes.
It has been demonstrated that neutrophils are indispensable for its anti-tumour effectiveness.
Previous work demonstrates that Ahr is indispensable for IDO production [ 88].
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CEO of Professional Science Editing for Scientists @ prosciediting.com