Sentence examples for indispensable for activity from inspiring English sources

These data are in agreement with the structure, suggesting that the conserved substrate-binding groove near the sugar nucleotide is important for peptide binding, the TPRs near the active site are indispensable for activity towards all protein substrates, whereas the TPRs nearer the N terminus could contribute to recognition of specific proteins.

Trans-autophosphorylation of PERK activation loop (residues 953 990) is indispensable for its activity [ 66].

CBFβ is indispensable for Runx1 activity in cells of the hematopoietic lineage because of its role in enhancing the DNA-binding activity and stability of Runx1 proteins (Adya et al., 2000).

As expected, the EGFRvIII/C16S + D837N mutant was not able to activate the EGFRvIII/V948R mutant indicating that the receptor dimerization is indispensable for EGFRvIII activity (Additional file 2: Figure S1B).

Specifically, the substituent at 7-position is indispensable for inhibitory activity.

Muscles express MCT1, MCT4 and CD147, an ancillary protein, indispensable for the activity of MCT1 and MCT4.

Moreover, synthesis of ferric reductase Cfl1 was upregulated, possibly to allow for capture of iron (III) ions, which are indispensable for Cat1 activity (Hammacott et al. 2000).

Structure activity relationship studies revealed that phenyl substitution at the 2-position of the pyrimidinone ring is indispensable for high activity.

Further decrease in lipid content in chloroplasts specifically MGDG and DGDG (Nouairi et al. 2005), considered to be indispensable for PSII activity, causes structural disorganisation of PSII supramolecular structure (Quartacci et al. 2000).

Several aromatic residues in the aglycon subsites that make strong substrate protein interactions and that are indispensable for enzyme activity, were also important for the specificity of the xylanase.

Herewith, we report the design and synthesis of a series of N- 2-oxo-2((4-oxo-2-substituted thiazolidiN- 2-oxo-2o)ethyl) beN- 2-oxo-2rivatives 7(a–j) uN- 2-oxo-2wave irradiation, based on four component pharmacophoric model to get structural prerequisite indispensable for anticonvulsant activity.