Sentence examples for indispensable for activating from inspiring English sources

Given that Ras is indispensable for activating PI3K in the endosomes [19], these results together underscore an important role for the Ras PI3K pathway in PIP3 production in early endosomes upon viral infection.

Stimulation of TLR signaling with LPS appeared indispensable for activating the IL-32α-TNFα axis in vivo.

This study revealed that IL-32α contributed to the development of LPS-induced inflammatory arthritis and endotoxin lethality; therefore, stimulation of LPS appears indispensable for activating the IL-32-TNFα axis in vivo.

ATM was found indispensable for the activation of MAP kinase p38, which catalyzes the activating phosphorylation of p53 on serine 46, thereby causing p53 dependent apoptosis.

As expected, the EGFRvIII/C16S + D837N mutant was not able to activate the EGFRvIII/V948R mutant indicating that the receptor dimerization is indispensable for EGFRvIII activity (Additional file 2: Figure S1B).

This oxidative signal is indispensable for T cell activation.

Some contacts are indispensable for undertaking some activities.

Although NF- κB has so far been implied in activating an autocrine/paracrine TNF α loop that drives Smac mimetic-induced apoptosis, we now identify IRF1 as an additional transcriptional activator that is activated by BV6 and indispensable for full induction of TNF α and apoptosis.

In addition, an increase in de novo lipid synthesis is also indispensable for tumor proliferation [ 32]. mTORC1 activates sterol regulatory element-binding protein (SREBP -1 and induceSREBP -1synthesis [ 33]. mTOR inhibitors reduce tumor progression and growth through SREBP-1.

But which pathway is indispensable for prolonged lifespan by CR, inhibiting TOR or activating sirtuins?

But here is a second debate: which is indispensable for prolonged lifespan by CR, inhibiting TOR or activating sirtuins?