"Freedom to think as you will and to speak as you think are means indispensable to the discovery and spread of political truth," wrote Supreme Court legend, Louis Brandeis.
Although significant progress has been made in experimental high throughput screening (HTS) of ADME (absorption, distribution, metabolism, excretion) and pharmacokinetic properties, the ADME and Toxicity (ADME Tox) in silico modeling is still indispensable in drug discovery as it can guide us to wisely select drug candidates prior to expensive ADME screenings and clinical trials.
The freedom to speak and express is thus crucial for the formation of public opinion on political questions, and is indispensable to the discovery and spread of political truth.
We suggest that this strategy of data mining is not only useful, but also indispensable, when the discovery of homologous sequences in a given dataset is in need of optimization.
A search for Synoviolin substrates is also indispensable for the discovery of any as yet unknown crosstalk between signaling pathways involved in the regulation of the cell cycle and/or apoptosis and Synoviolin, which could help to uncover the complex pathogenic mechanism of RA.
For the relatively few discoveries that represent more than noise or mere curiosities, randomized trials are indispensable to find out what they can really achieve.
But nowhere is there a tip of the hat to the canine and equine contributions, which historians and polar experts agree were, in the case of the dogs at least, indispensable in early Antarctic discovery.
This review focuses on the dramatic advances in the chiral stationary phases (CSPs) that have made HPLC and SFC indispensable techniques for drug discovery today.
Preclinical models of human cancers are indispensable in the drug discovery and development process for new cancer drugs, small molecules and biologics.
Service discovery is indispensable to ad hoc networking where establishing a stand-alone and self-configurable communication environment is the main objective.
