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The present data indicate very clearly that stable alterations in the fibroblasts themselves are indispensable for (auto antibodies to exert their effects on IL-16 (and RANTES) mediated chemoattraction.
Several additional genetic alterations including the activation of telomerase are indispensable for immortality [ 9].
These steps involve the sequential acquisition of genetic and epigenetic alterations which provide a level of cellular plasticity that is indispensable for the completion of the metastatic process [ 2, 3].
Considering that macrophages are widely distributed immune cells that play an indispensable role in homeostasis and defense, we investigated the immunomodulatory effect of andrographolide on the alteration of macrophage phenotype and function.
It is possible that alterations in the expression levels of these miRNAs contribute to trastuzumab sensitivity by targeting additional genes that are indispensable for the acquisition of resistance in breast cancer cells in vivo.
Thus, genetic alteration or expression status is possible to be a landmark for molecular-targeted therapy, and it is indispensable to evaluate the anticancer activity of PRL-3 inhibitor treatment against cancer cells with different genetic and expression status.
Furthermore, analyzing copy number alterations data from 1,547 cancer patients reveals that 56 genes that are frequently amplified or deleted in nine different cancers are indispensable.
Indispensable, then.
But he seems indispensable.
It is indispensable.
Lopez now seems indispensable.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com