These data are in agreement with the structure, suggesting that the conserved substrate-binding groove near the sugar nucleotide is important for peptide binding, the TPRs near the active site are indispensable for activity towards all protein substrates, whereas the TPRs nearer the N terminus could contribute to recognition of specific proteins.
TC's second core principle holds that patient advocacy is an indispensable physician activity.
Trans-autophosphorylation of PERK activation loop (residues 953 990) is indispensable for its activity [ 66].
As expected, the EGFRvIII/C16S + D837N mutant was not able to activate the EGFRvIII/V948R mutant indicating that the receptor dimerization is indispensable for EGFRvIII activity (Additional file 2: Figure S1B).
CBFβ is indispensable for Runx1 activity in cells of the hematopoietic lineage because of its role in enhancing the DNA-binding activity and stability of Runx1 proteins (Adya et al., 2000).
Specifically, the substituent at 7-position is indispensable for inhibitory activity.
In particular, he recognizes that prescription and proscription are (a) different from description and (b) indispensable to human activity.
Muscles express MCT1, MCT4 and CD147, an ancillary protein, indispensable for the activity of MCT1 and MCT4.
Moreover, synthesis of ferric reductase Cfl1 was upregulated, possibly to allow for capture of iron (III) ions, which are indispensable for Cat1 activity (Hammacott et al. 2000).
Structure activity relationship studies revealed that phenyl substitution at the 2-position of the pyrimidinone ring is indispensable for high activity.
