Conversely, the basal level of phospho-Akt present in the serum- and estrogen-deprived cells, with or without ICI 182780, is sufficient to supply the indispensable activity of the Akt kinase needed for the full mitogenic activity of the E2/ER complex.
Power is indispensable for activities such as lighting, refrigeration, heating, cooling and commerce and development more broadly.
These data are in agreement with the structure, suggesting that the conserved substrate-binding groove near the sugar nucleotide is important for peptide binding, the TPRs near the active site are indispensable for activity towards all protein substrates, whereas the TPRs nearer the N terminus could contribute to recognition of specific proteins.
"But if an activity is 'an integral and indispensable part of the principal activities for which covered workmen are employed,' then the time it takes to do the activity should be paid for, the Supreme Court ruled in Steiner vs. Mitchell in 1956.
AMPA receptors are the principal excitatory neurotransmitter receptors in the brain and are indispensable for brain activities, such as memory and learning.
Several aromatic residues in the aglycon subsites that make strong substrate protein interactions and that are indispensable for enzyme activity, were also important for the specificity of the xylanase.
Trans-autophosphorylation of PERK activation loop (residues 953 990) is indispensable for its activity [ 66].
Moreover, synthesis of ferric reductase Cfl1 was upregulated, possibly to allow for capture of iron (III) ions, which are indispensable for Cat1 activity (Hammacott et al. 2000).
As expected, the EGFRvIII/C16S + D837N mutant was not able to activate the EGFRvIII/V948R mutant indicating that the receptor dimerization is indispensable for EGFRvIII activity (Additional file 2: Figure S1B).
CBFβ is indispensable for Runx1 activity in cells of the hematopoietic lineage because of its role in enhancing the DNA-binding activity and stability of Runx1 proteins (Adya et al., 2000).
EED, a core component of PRC2, is indispensable for PRC2 activity.
