In addition, we now know that the protein does not just stimulate angiogenesis, an action indispensable in the regeneration of tissue, but also increases the production of various types of extracellular matrix from HPDLs [21], [35] [37].
In contrast, dominant-negative p38 and p38 inhibitor abrogated PL-induced autophagy and cell death, suggesting that p38 signaling is indispensable for the action of PL.
Asked about that assertion, United States officials pointed to comments by Secretary of State Colin L. Powell indicating that language that could provide the basis for military action remains indispensable.
"Considering the current political climate, in which an increasing number of citizens question the foundations of the EU, decisive action is indispensable," an assessment of the programme by officials in the European parliament reports.
Particularly, calcium alkoxides, acting as precursors of corresponding carbonate [14,15], can be considered for stone strengthening as an indispensable and essential preliminary action for its conservation, as demonstrated within the bilateral Italian-French GALILEO Project [16].
Furthermore, store-operated calcium entry is indispensable for the cytotoxic action of CTLs.
In order to estimate the potential human health impacts of nanoparticles a precise knowledge on their mechanism of action is indispensable.
A comprehensive understanding of the mechanisms underlying drug action is indispensable for predicting and evaluating drug efficacy and safety, and for directing therapeutic efforts.
Spatial targeting of conservation actions is indispensable to protect and maintain farmland biodiversity and associated ecosystem services.
Large-scale information on habitat suitability is indispensable for planning management actions to further endangered species with large-spatial requirements.
These actions are indispensable, and may form the seeds of a new movement, but people should not ignore one of the most powerful means of resistance and protest that they have: their roles as workers.
