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CDK1/2 phosphorylation is thus indirectly maintained by Chk1, and removal of the latter may promote further reduction of pCDK1/2.
In light of this consideration, Ib WRKY1 played a direct role in the defense against herbivore and, indirectly, maintained JA level for sporamin- activated defense.
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Moreover, sulfated gastrin seems to indirectly maintain the homeostasis of blood glucose through the down-regulation of insulin in ruminants.
We evaluated whether ecosystem engineers can accomplish two conservation goals simultaneously: (1) indirectly maintain populations of an endangered animal through habitat modification and (2) increase riparian plant diversity.
Our results confirmed what others have found about engineering effects on plant diversity, but these results further demonstrated a case where ecosystem engineers indirectly maintain populations of rare animals by modifying the composition and diversity of plant communities within wetlands.
Based on this model and on our results showing the critical role of the LAT tyrosines in the Lck/LAT association, we propose that LAT may indirectly maintain active Lck close to substrates and/or stabilize Lck in an open conformation by engaging its SH2 and SH3 domains.
p38 MAPK activity may indirectly maintain Rab5 in an inactive GDP-bound form (Cavalli et al., 2001; Vergne et al., 2004a;).
Alternatively, RNA polymerase activity may indirectly maintain a chromatin state that promotes the binding of HJURP, and therefore the subsequent deposition of newly synthesized CENP-A (depicted in Figure 8).
Thus, Polycomb proteins may indirectly maintain oct-4, sox-2, and rex-1 activation in MSCs; alternatively, Trithorax proteins, which complement Polycomb proteins [ 27] by maintaining the activation of homeotic genes, may directly regulate the expression of oct-4, sox-2, and rex-1.
Given the early and transient nature of HSF1 activation during monocyte differentiation, HSF1 may first act directly like a sensor to initiate the differentiation process by inducing the transcription of SPI1/PU.1; HSF1 can then indirectly maintain the macrophage differentiation transcriptional program though the expression of HSP70, which stabilizes SPI1/PU.1.
Campaigners need to find ways to engage, either directly or indirectly, while maintaining their values.
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