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The 'high-road' affective/cognitive processes, by contrast, involve an indirect pathway to the amygdala.
The indirect pathway consists of striatopallidal MSNs that project to the external globus pallidus.
For acetone and HFiP, only the second, indirect, pathway with the participation of OH radicals is effective.
The indirect pathway concerns a larger proportion of the human and animal population than the direct infection pathway.
Activation of the indirect pathway removes the inhibition of the external globus pallidus on the subthalamic nucleus.
Until recently, the vigorous T cell response via the direct pathway has overshadowed studies involving the indirect pathway.
The proliferative response was primarily mediated by CD4+ T cells recognizing the RT1.Aa molecule via the indirect pathway.
"Our work shows that the indirect pathway could be the significant path to humans and the environment," says Mabury.
Ammonia electrooxidation proceeds on NiOOH phase and follows the direct pathway at low concentrations and indirect pathway at higher concentrations where NiOOH is reducing and NH3 is oxidizing.
Stimulation of these Gi mediated receptors inhibits AC resulting in an inactivation of the indirect pathway (Fisone et al. 2007; Traynor and Neubig 2005).
According to Frenzel's (2014) review of research, an indirect pathway, often referred to as emotional crossover, seems to be particularly suitable to explain such processes.
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