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aiT also takes into account user annotations such as upper bounds on loop iteration counts, recursion depth, targets of indirect function calls, etc.
The results suggest that mtr1p and at least one other predicted ribosome complex protein, rps1801p, have direct or indirect function in modulating microtubule dynamics.
Incomplete centrosome separation probably reflects an indirect function of Dia, as no obvious centrosomal localization of Dia has been reported yet.
Although, a direct role of plant APCs in ATP-Ca transport is therefore arguable, recent data suggest an indirect function of a mammalian isoform in Ca2+ translocation.
Similarly, since LIS disrupts transcription complexes (27), the SARs thus isolated were expected to support an indirect function, such as potentiation, to spatially poise rather than direct the interaction of the nuclear scaffold with the transcription factory (37).
However, indirect function tests can detect a decreased amount of pancreatic enzymes in stool or serum or, alternatively, evaluate the digestion of synthetic substrates that are administered orally [ 30].
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In contrast to apparently indirect functions of NEDD8's residue 72, ubiquitin's Arg72 mediates important positive interactions with many cognate partners.
Since lactotropes in the rat lack PR expression (Fox et al. 1990), it has been suggested that progesterone might exert indirect functions on lactotropes via actions on gonadotropes (Freeman et al. 2000).
Together, there is now clear evidence of nucleolin's involvement in cancer cell behavior and response to HGF, although this protein's direct and/or indirect functions remain to be discovered.
The proteinogenic amino acid L-methionine has many essential direct and indirect functions in cellular metabolism, including ethylene biosynthesis [ 49], as well as the biosynthesis of defense compounds [ 92].
Thus, deletion of Bcl11b in a fraction of dentate neurons suffices to impair neuronal differentiation in surrounding wild-type cells (as determined by the piling-up of NeuroD expressing, immature cells), a phenotype that is compatible with indirect functions of Bcl11b in neuronal differentiation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com