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It also explains why the indirect effect, but not the direct effect can become negative.
Our SEM further showed that continent had strong indirect effect but weak direct effect on AMF.
This could be an indirect effect, but it could be due to Hfq binding/stabilizing the RydC pseudoknot fold and inhibiting degradation from the 5' end.
Given these three variance components, there are at least two defensible ways to divide variance explained over the direct and indirect effect, but neither of them is without disadvantages.
These data suggest that the reduced XBP1u mRNA splicing in the SRP pathway knockdown experiments is not an indirect effect but a result of reduced XBP1u mRNA targeting to the ER membrane.
In the present article, squared betas were useful for explaining the interconnectedness of the direct and indirect effect, but as measures of unique variance explained they are too hypothetical for almost all research situations in the social sciences.
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Ecosystems, biogeographical realms, climatic zones, and continents had relatively stronger direct effects on plants than indirect effects, but stronger indirect effects on AMF than direct effects.
The X-ray data represent a static structure whereas shifts in NMR resonances could represent indirect effects, but will certainly also reflect perturbations that arise from solution dynamics.
Transitive reduction is one approach for eliminating edges reflecting indirect effects but its use in reconstructing cyclic interaction graphs with true redundant structures is problematic.
The authors did not address the removal of edges from indirect effects but they mentioned it as a potential means to improve the results.
The modeling approach is inherently limited to make predictions about proteins on the protein array in the perturbation screen and edges represent indirect effects, but the experimental/computational technique – in particular the focus on quantitative, predictive instead of descriptive networks – is powerful when there is sufficient coverage on the protein array.
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CEO of Professional Science Editing for Scientists @ prosciediting.com