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Planning for indirect comparisons.
The percentage contribution of each direct and indirect comparisons is presented as a table in Supplementary Figure S6.
Indirect comparisons between treatment arms of different trials were made using metaregression.
Many areas permit direct comparisons, but some areas only permit more indirect comparisons.
Indirect comparisons suggest that the effects of Co differ between sheep and cattle.
We used the Bucher method for conducting adjusted indirect comparisons within a meta-analysis.
Indirect comparisons can be performed as adjusted indirect comparisons, unadjusted indirect comparisons and mixed-treatment-comparisons (MTC).
Figure 1 Adjusted and unadjusted indirect comparisons.
Direct and indirect comparisons Direct comparison preferred; indirect comparison possible.
The Haute Autorité de Santé (HAS) accepts adjusted indirect comparisons as a valid method of indirect comparisons.
The FDA generally considers such indirect comparisons misleading.
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