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Statistically significant correlations in MSAs that do not reflect interactions between residues in contact, that is, false positives, can stem from (i) various indirect physical interactions and (ii) common ancestry.
So the non-African ancestry predicted in these populations could be through indirect contribution from their ancestral populations.
Wavelets provide indirect information on the block structure, thus providing an alternative over methods that assign ancestry directly (Sankararaman et al. 2008; Price et al. 2009).
Pugach et al. (2011) also use PCA, but do not directly assign ancestry to genomic regions, instead applying a wavelet transform to obtain an indirect measure of the average admixture block length.
The most remarkable outlook that this review is trying to represent here for the first time is the potential application of DNA methylation profiling to identify the human biogeographic type (racial), ancestry and phenotypic type (ethnicity), or certain criminal behaviour which may aid in gathering unseen (abstract) indirect evidences for some critical forensic cases.
Crusader ancestry?
Jewish ancestry.
Indirect lighting.
Johnson's ancestry.
Explore your family ancestry.
How indirect!
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com