S.J. Garcia et al. (2001) state that "measurement just of cholinesterase activity is a questionable approach in assigning an appropriate index of safety".
We could look for a single defining index of safety; we might think of safety in terms of a set of core standards; we might seek it in the attitudes and behaviours of staff, perhaps in terms of safety culture.
Phase I clinical trials for Leber congenital amaurosis (LCA), a rare, blinding retinopathy, established both indexes of safety and improved visual function, despite the small size and safety focus of first-in-human phase I clinical trials [ 6- 8].
It has a very high therapeutic index of safety as a hypnotic agent, the lethal dose being up to 12 times the hypnotic dose, providing a good safety profile among all the other available induction agents [ 5- 7].
Instead, it may be necessary to observe the rate of resolution of the acute toxicity and use this as an index of safety and tolerability (Harrington et al, 2009 ).
Gill SV, Narain A. Quantifying the effects of body mass index on safety: reliability of a video coding procedure and utility of a rhythmic walking task.
More recently, studies demonstrate the impact of team-training programmes on clinical processes, as well as indices of care safety and quality.
While calculating the liquefaction potential index, factor of safety is integrated over depth with a weighting function.
In this study, both the FHDMR and HHDMR are applied to the reliability index calculation of safety factors related to the stability analyses of sliding failure mechanisms in complex formations.
The results showed that, compared to CCP, RGICF had a lower emergy yield ratio by 0.62, lower systematic self-organization ability by 0.07, lower environmental loading ratio by 0.51, 1.32 times higher emergy sustainable index, and 2.14 times higher emergy index of product safety.
