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A number of indices of efficacy can be calculated from the data, including the IC90.
Several indices of efficacy, such as T/N downstaging, pCR, and ypT0-2N0, have been demonstrated as prognostic factors in LARC patients [ 30– 30].
Other potential benefits of TSPO ligands are more sensitive indices of efficacy allowing early identification of nonresponder patients and improved evaluation of efficacy in animal models where determining the level and extent of microglial activation may provide a more relevant outcome measure.
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Forty-five molecules were identified as hits that gave a DCF decrease of at least 40% and an index of efficacy to toxicity of over 30 (Fig. 3c).
Unfortunately, it was easy to demonstrate that response rate and overall survival were not always correlated; response rate was classified as an index of activity and overall survival as an index of efficacy of a treatment, using response rate as a surrogate index of efficacy in clinical practice.
Antiangiogenic drugs are typically cytostatic in their mechanism of action and consequently tumor reduction may be a less valuable index of efficacy.
Plotting the antioxidant ability against the index of efficacy relative to toxicity provided a way to identify the molecules that scored well on both measures.
The minimum airway pressure below the PEEP level and the airway pressure swing around PEEP were used as indexes of efficacy.
To identify such molecules, the data were analyzed in two ways and the molecules were ranked according to two different parameters: (1) antioxidant ability (measured by DCF reduction), regardless of concentration, and (2) index of efficacy relative to toxicity, which considered the window between an effective dose and a toxic dose.
Lurie is concerned about moving away from the basic index of efficacy--extended survival.
We measured collectivization among FSWs in terms of three binary (low, high) indices of collective efficacy, collective agency, and collective action.
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CEO of Professional Science Editing for Scientists @ prosciediting.com