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To measure RA disease severity in medical records, we defined a set of indicators of severe RA through an expert Delphi panel of rheumatologists [ 16].
Systolic velocities of more than 250 300 cm/s are sensitive indicators of severe mesenteric arterial stenosis.
Thus, we selected detoxified drinkers with moderate alcoholism, i.e. with no clinical evidence of brain dysfunction or medical conditions considered to be clinical indicators of severe alcoholism (e.g. alcohol-induced dementia or chronic liver disease [25]).
Although the current study did not directly address whether ANG-1 and ANG-2 could be used to predict which patients with uncomplicated disease will progress to cerebral malaria, our results clearly demonstrate that ANG-1 and ANG-2 are sensitive and specific indicators of severe disease that effectively differentiate between uncomplicated malaria and CM.
However, they did not identify the most important clinical indicators of severe illness.
Elevated lactate dehydrogenase, creatine phosphokinase, and creatinine at hospital admission may also serve as prognostic indicators of severe disease [ 14].
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In clinical severe sepsis, high cortisol levels have been reported in patients who developed fatal brain dysfunction [ 12] but it remained unclear if this could be a sole indicator of severe inflammation and disease severity or was due to brain dysfunction.
We examined the association of both these derived severity classifications and the clinician's overall diagnosis of the severity of disease with death as the gold standard indicator of severe disease.
Finally, the HI, which was conceived to study the occurrence of severe meteorological events, is described in "An indicator of severe rainfall: heterogeneity index (HI)" section.
Conclusion: The vascular endothelial growth factor system is up-regulated in response to placental hypoxia and is assumed to be a potential early indicator of severe birth asphyxia.
In addition, to get a sense of how job loss affects the incidence of severe depressive symptoms, we re-estimated our models with a binary indicator of severe depressive symptoms.
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