This progression of the disease may also be considered to be an indicator of progressive biomechanical weakening.
Post-treatment elevation of serum CA125 level in EOC patients serves as an indicator of progressive disease and finds clinical application in the management of patients with documented evidence of ovarian cancer [3]-[7].
LPS-induced pulmonary oedema that the continuous measurement of inspiratory resistive work is a good indirect indicator of progressive lung oedema [ 1].
The increased vesicularization during cold stress can be an indicator of progressive membrane damage as reported under other stress situations [ 31].
Therefore, sHA may have potential as a prognostic indicator of progressive knee OA, but the relationship between sHA and knee OA has only been examined in a few longitudinal studies [ 19, 20].
In the case of this patient, even though the IOP reduction near 30%% was obtained, after 8 months of treatment, the PERG amplitudes were not higher, but did not differ much with the initial values, what was another indicator of progressive destruction of RGCs, typical for glaucoma.
Measurement of retinal thickness has been used as an indicator of progressive neural retinal pathology in animal models of retinal degeneration, but the degree of degeneration that occurs in diabetic animals is considerably less than in retinal degeneration models and is more difficult to measure reproducibly.
What should be the indicators of progress?
Based on the results of our analysis, a rising/nondeclining CA19-9 appears to be a clear indicator of early progressive disease and to correlate with very poor clinical outcomes.
We should not forget that approximately 30 years ago, dealing with similar patients, Viberti et al. (1) reported "proteinuria of this degree (≥0.5 g/24 h) is the earliest indicator of a progressive and relentless decline of glomerular function leading a few years later to end-stage renal failure".
