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Although the precise mechanism of action of Wld s remains controversial, several in vivo and in vitro genomic and proteomic studies have identified downstream modifications in the expression of genes and proteins (focused around cell-cycle status, cell stress and mitochondrial stability) that are robust indicators of modified axonal and synaptic vulnerability (29– 31).
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As an indicator of modified calcium homeostasis, we confirmed upregulated RyR levels in A246E-PS1 overexpressing cortical neurons [ 92].Given the prominent role of dendritic calcium signalling in dendritic spine plasticity, we, therefore, favour the view that PS1-dependent changes in calcium homeostasis underlie the elevated spine densities in PS1-transgenic mice.
The key conclusion is that endemic species richness is a potentially powerful indicator for conservation evaluation of modified habitats.
Three of the indicators were modified or refined.
The AWI used indicators that were in the original TGI35L/2000 [ 5], some of these indicators were modified and new indicators were used in the present study.
The first component of the questionnaire is comprised of morbidity indicators modified from the IMCI Chart.
The presence of indicators modifies the predefined probabilities of each COD upward or downward using Bayes' theorem.
One potential indicator of the potential value of modifying the care pathway towards same-day discharge can be found within the DRGs for interventional and diagnostic procedures which include cost for hotel and general wards at an amount of approximately €400 per patient.
Studied indicators were modified and adapted similarly to the WHO indicators of maternal near miss.
However, the operational definitions for the selected indicators were modified and contextualised according to the requirements of this assessment.
Some indicators were modified or combined due to overlap between categories or pragmatic reasons concerning implementation, resulting in a final consensus-based set of indicators.
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CEO of Professional Science Editing for Scientists @ prosciediting.com