Phospho-Histone (H3) is an indicator of mitotic activity.
MPM-2 is commonly used as an indicator of mitotic disturbance.
MPM-2 is an antibody that recognises a group of proteins whose epitopes are exclusively phosphorylated during mitosis – particularly early prophase to metaphase (Davis et al, 1983) and it is commonly used as an indicator of mitotic disturbance.
The M phase indicator mitotic index, the number of mitotic bodies in a microscopic field, and the S-phase fraction, a DNA flow cytometry determination, are used to measure the tumor proliferation rate and are predictive for breast cancer prognosis [ 2- 4].
Therefore, telomere length may serve as another good indicator for mitotic history and the prospective additional life span.
Mitotic indices also demonstrated similar numbers of mitotic cells in control and chrysotile-treated cells.
The poor prognostic indicators of DFSP include advanced age, high mitotic index, increased cellularity, DNA aneuploidy and fibrosarcomatous changes within the tumor.
In addition, we noted elevated protein levels of mitotic cyclins CCNB1 and CCNA2 indicative of a mitotic arrest (Fig. 4d).
Visualization of mitotic spindle with fluorescent microscopy indicated that LJK-11 caused multipolar mitotic spindles.
Metabolic profile of mitotic arrested cells.
