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However, the severe root growth defect observed in exocyst mutants could not be convincingly associated with any of several indirect indicators of altered auxin transport or signaling.
This suggests that cross-validated point mutations may indeed be important indicators of altered molecular processes indicative of potential transformation.
Moreover, indicators of altered osmoregulation in Mecp2-null mouse brain suggest another link to changes in brain size, potentially caused by neurons and astrocytes.
Thus, measure of these markers may be viewed as early indicators of altered structure or function.
We examined expression of Cyp1a1, Cyp1b1, and Comt as indicators of altered E2 metabolism capability in the mammary gland cohort mice.
Differences amongst the groups in product/substrate ratios within the pathways as potential indicators of altered enzymatic processes were assessed by calculating their respective Pearson correlations.
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The change in the FA composition may be regarded as an indicator of altered lipid metabolism occurring in vivo during human bladder tumorigenesis [84].
In advanced lung cancer, phase angle was speculated to be an indicator of altered tissue electrical properties [ 34].
Vacuolation has been shown as an indicator of altered acidification through a proton "trapping" mechanism [ 25] and inhibition of key lysosomal enzymes, including cathepsin D [ 30].
Professor Doré stressed that alternative stable states of gut microecology may be associated with immune-mediated disease conditions, and that reduced microbial diversity is a robust indicator of altered intestinal ecology and physiology.
In this view of disease, alterations in Aβ expression would only be a part player in pathology or, perhaps even, a by-product, and an indicator of altered APP function and cleavage.
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