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Multiple behavioural risk factors were strongly associated with estimated CVD-risk, but improving trends in traditional CVD risk factors were inconsistent with increasing indicators of adiposity.
There was an inverse association between indicators of adiposity (BMI, waist and hip circumferences, waist-to-hip ratio, and percentage of fat in the trunk and whole body) and LogEEPAmoderate.
Possible over-adjustment could explain why we observed some evidence for effect mediation by 25(OH D on our seasonal modeling of fibrinogen, while the inverse relation seen in the unadjusted cross-sectional analyses between these two factors was fully attenuated by the adjustment for indicators of adiposity and lifestyle/social class.
In our model, we found a significant relation between leptin and DHEAS that disappeared after adjustment for indicators of adiposity.
In this analysis, different indicators of adiposity were considered because no perfect measurement of adiposity is applicable for large epidemiological studies.
However, the BMI has some limitations as an indicator of obesity (13), and no study has been reported on the relationship with other indicators of adiposity.
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Thus, among patients with heart failure, these authors stated, "body mass index may not be a good indicator of adiposity".
It was noteworthy that FMI, an indicator of adiposity, did not show much appreciable effect.
Based on this result we used the weight of one or more fat pads (if dissectible) as an indicator of adiposity when MRI was not available.
Thus, the accuracy of BMI as an indicator of adiposity decreases with increasing age (7).
We did not measure waist circumference, which may be a better indicator of adiposity in Asians (24).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com