Sentence examples for indicator of stem from inspiring English sources
The nonlinear relationship, however, suggests that birth weight is not an unequivocal indicator of stem cell potential in the context of a prenatal origin of cancer risk.
Presence of the cyclin A2 transcript at a high level therefore serves as a good indicator of stem cell activity in our root meristem section.
These data support the idea that replicative potential of HSCs could be limited by progressive telomere shortening and that telomere length can be used as an indirect indicator of stem cell proliferative history and potential.
Mammospheres derived from 4 T1-Luc-Oct3/4pG cells were examined for Oct3/4 expression, as an indicator of stem properties, since Oct 3/4 transcription factor is a known stem cell marker, which was shown to be critical for maintaining stem cell characteristics [ 36].
In breast tissue, the Notch signaling pathway was shown to be upregulated, and inhibition of the Notch pathway reduced the formation of mammosphere, an indicator of stem-like cells [ 56].
Although markers of stem-like cells are debated in the field, many groups agree that high expression of aldehyde dehydrogenase is a strong indicator of stem-like characteristics (Huang et al, 2009).
Consistent with the other indicators of stem cell properties described above, we found that expression of vimentin, SLUG and FOXC2 was increased in PROCR+/ESA+ cells relative to PROCR−/ESA− cells, while expression of E-cadherin was lower.
Levels of hematopoietic stem cells were therefore used in this study as proxy indicators of stem cell burden to correlate with cord blood plasma levels of endocrine factors, which represent the in utero concentrations of these factors.
Specifically, mitochondrial structure and function have been suggested to be indicators of stem cell competence because low mitochondrial activity and relatively under-developed mitochondrial networks have been confirmed to be common features of stemness [ 43- 48].
Although the progenitor cell markers analyzed in this study can not be considered alone as representative indicators of stem cells within human articular cartilage, the increased presence of such molecules in OA tissue, in particular in cell clusters, further implicates their involvement in the abnormal matrix remodeling process.
