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They induce apoptosis and glucocorticoid responsiveness is an early indicator of response to chemotherapy in general.
This supports the feasibility of serial FDG SUV as an early indicator of response to endocrine therapy.
Rowe et al., therefore, also considered the utility of SUVmax calculations in lesions as a prognostic indicator of response to systemic therapy such as tyrosine kinase inhibitors (TKI).
Further study is needed before drawing any conclusions about the efficacy of FDG PET as an early indicator of response to trastuzumab or other HER2-targeted therapies.
In high-grade glioma (HGG), 18 F-FDG PET is an indicator of response to therapy and is used for PET-guided planning of stereotactic brain biopsy [2 5].
The use of SUVmax for discrimination between benign and malignancy for soft tissue masses and lymph nodes has been demonstrated for lung cancer patients [8],[9] and changes in SUVmax used as an indicator of response to therapy [10].
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As we were interested in early MRI indicators of response, we first confirmed the responsiveness to 4 days of selumetinib treatment in the BRAFV600D mutant WM266.4 human melanoma xenograft model.
Our results indicate HR and HER2 status are dominant indicators of response in the absence of TOP2A and PS17 amplification.
Despite the widespread use of these indices in clinical trials, their performance as indicators of response in individual RA patients is more problematic [ 1].
Development of regional indicators of response will also be essential to evaluate outcomes of management strategies.
Current indicators of response to breast cancer therapy rely on the hormonal status of tumour tissue.
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