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One enzyme which may be an indicator of impaired mitochondrial function is cytochrome oxidase.
It is just an indicator of impaired OHRQoL.
According to the research team, increases in such symptoms may be an early indicator of impaired neurological function.
Chronic fatigue was included as a further indicator of impaired mental health as assessed by a 4-item-scale that was developed in a Dutch study [ 28].
The aim of this study was to evaluate the potential of near-infrared spectroscopy as a direct and early indicator of impaired tissue oxygenation after cardiac surgery.
While early resuscitation of patients with severe sepsis and septic shock focuses on optimizing hemodynamics and oxygen delivery [ 8], lactate may be an indicator of impaired microcirculatory perfusion and often is the only indicator of severe sepsis [ 9].
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A subgroup of heavy or problem drinkers showed a large range of emotional and behavioural problems and further indicators of impaired psychosocial functioning both in late adolescence and young adulthood.
For example, at 3 months of age, multiple upstream indicators of impaired immune function were detected in breast-fed infants with higher PCB exposure levels, including reduced numbers of white blood cells and lymphocytes, and lower serum IgA levels at 7 and 12 months of age (Dewailly et al. 2000).
Leukoencephalopathy related to vasogenic edema is also an indicator of severely impaired venous outflow (Kawaguchi et al 2001).
Monitoring the redox state of cytochrome aa3 might therefore be a key indicator of an impaired cellular oxidative metabolism and tissue dysoxia.
Until then, the OGTT, a sensitive indicator of diabetes and an early marker of impaired glucose homeostasis (18), is the better diagnostic option for T1D.
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