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CONCLUSION: Our autopsy analysis confirms the validity of carotid IMT including plaque thickness as an indicator of generalized atherosclerosis.
BACKGROUND: Ultrasound-determined carotid intima-media thickness (IMT) is widely used as an indicator of generalized atherosclerotic burden, but there are limited autopsy findings in support of the association, directly.
In this group, fecal incontinence may be an indicator of generalized bowel dysfunction rather than an isolated anal sphincter problem as it may be in a younger population [ 19].
It has been suggested that albuminuria not only reflects glomerular damage, but also serves as a sensitive indicator of generalized endothelial dysfunction and capillary vasculopathy that leads to penetration of atherosclerotic lipoproteins into the arterial wall [ 36- 38].
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This supports the concept that retinal microvascular signs are indicators of generalized microvascular disease even in the absence of diabetes, and reinforces the link between retinal and renal microcirculations.
Administration of obatoclax did not result in animal weight loss or other indicators of generalized toxicity, but sometimes led to neurological toxicity at high doses, 58, 62, 63, 69 foreshadowing adverse events to be noted in clinical trials.
Subclinical atherosclerosis precedes cardiovascular disease (CVD) and an increased intima media thickness (IMT), measured by ultrasonography, is regarded as an early indicator of a generalized atherosclerosis [ 7].
Time was used as an indicator of the generalized cost of a particular travel mode but the inclusion of time in the specified models would have been strengthened if we had information on the travel times for each alternative transport mode.
The EU social awareness of landscape indicator represents a new class of generalized social indicator using a top down methodology to capture the social dimensions of landscape without reference to the specific structural and cultural characteristics of individual landscapes.
The haplotype ATA of IL-10, as a "low interleukin-10 producer," was proved as a risk indicator for generalized aggressive periodontitis [ 56].
Focal thickening of Gerota's fascia contiguous with the tumor tends to be a more reliable indicator of invasion than generalized uniform thickening.
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