Sentence examples for indicator of dose from inspiring English sources
In almost all current Phase I designs, toxicity response is treated coarsely as a binary indicator of dose limiting toxicity (DLT) and a lot of useful toxicity information is discarded.
Chen et al. [1] proposed a novel normalized equivalent toxicity score (NETS) system to fully utilize multiple toxicities per patient instead of a binary indicator of dose limiting toxicity (DLT).
However, this design treats the toxicity response as a binary indicator of dose limiting toxicity (DLT) and does not account for the number and specific grades of toxicities experienced by patients during the trial.
Using the NHP model, C-reactive protein (CRP), SAA, IL-6, Flt3L protein biomarkers expressed in NHP plasma have been proposed as early indicators of dose assessment and radiation-induced injury up to ~7 days post irradiation12,13.
This study showed the usefulness of 1-hydroxypyrene as an indicator of internal dose of polynuclear aromatic hydrocarbons.
Another potential limitation of the study is the use of the DDD as an indicator of high dose prescribing.
The primary indicator of intervention dose will be number of home visits made per 12-month period.
The current regulation guidelines used by both national and international agencies are based on the assumption that hair Hg concentration is a valid indicator of oral dose and toxic end points for all populations.
Biomonitoring for insecticide metabolite concentrations in urine is a commonly used indicator of internal dose integrating the various routes through which the contaminant enters the body (Barr et al. 1999).
Whereas pollen concentration has been taken as the indicator of potential dose, the underlying mechanism for allergic symptoms comes in part from the protein allergens in the pollen (Ahlholm et al., 1998; Beggs, 1998; Singer et al., 2005).
