To assess the radioadaptive response of the whole body system in mice, we examined the temporal effect of low dose priming as an indicator of challenging irradiation-induced apoptosis through a p53 tumor suppressor protein- mediated signal transduction pathway.
How such violent practices, if proved, would have been able to persist for so long may be an indicator of the challenges that local law enforcement agencies face in trying conduct investigations of insular religious groups including the ultra-Orthodox.
Perhaps the biggest indicator of the challenges facing phone makers is the recent announcement that Nokia has formed an alliance with Microsoft to use its Windows Phone 7 software in its line of mobile devices, moving away from its own home-grown software.
Another indicator of osmoregulatory challenges in fish is the sodium-potassium ATPase (Na+, K+-ATPase), a membrane protein which maintains ion gradients required for cell homeostasis and whose activity in the gills is related to either active ion secretion in hyper-osmotic conditions or active uptake in hypo-osmotic conditions [ 18- 20].
In this setting the PAOP remains a good indicator of fluid challenge tolerance; a large increase in PAOP (5 10 mmHg) after one fluid challenge indicates that further fluid loading should be considered with caution.
Despite this methodological limitation, variation of these parameters during fluid loading remains a good indicator of fluid challenge tolerance.
Thus, it is plausible that, above and beyond the influence of family income and low maternal education, neighborhood social disadvantage may be an indicator of access and compliance challenges associated with unmet need among this vulnerable population.
In the area of indicators the challenges include the impact of ICT on accessibility; the inclusion of the robustness of the transport system in indicators; comparing perceptions of accessibility and traditional accessibility indicators; the option value; and the indicators of accessibility for goods transport, air transport, and slow modes.
Generating a robust indicator of PCCRC rates is challenging.
Taking this into account, the development of indicator faces several challenges and requirements [23, 24].
