However, it should be noted that expression of p16INK4A is not limited to HPV-positive tumors, and the use of this marker alone as an indicator of biologically relevant HPV infections inevitably entails the risk of including some HPV negative p16INK4A positive results [ 45].
In recent decades, several previous studies have confirmed that the elevated COX2 levels may be an indicator of biologically aggressive tumor prognosis based on its important role on tumor cells growth and metastasis [ 21, 22]; meanwhile other studies have also illustrated inconsistent results [ 8, 23].
However, the former biomarker was thought to be the best indicator of the biologically relevant concentration of mercury in the fetal circulation.
These species-defining unique differences seem trivial and certainly not strong indicators for biologically separate entities from other species of canid and icthyosaurs.
Therefore, Pho localization is a very good indicator of the presence of a biologically functional PRE.
Therefore, the presence of Pho at a given genomic region is a good indicator of the location of a biologically active PRE.
Estimates of modeled annual average mass concentration of particles < 2.5 μm in size (PM2.5) at residential addresses were used as a biologically relevant indicator of exposure to air pollutants because it has been shown to be associated with the investigated end point (Brook and Rajagopalan 2009; Brook et al. 2002).
Our results suggest that tumours can spread directly through the blood-vascular system from their initial growth sites, and that lymph-node status was still considered a powerful prognostic indicator; however, biologically the combination of AMC and BVI is more significant than lymph-node status for tumour haematogenous dissemination.
Recent progress in molecular biology has identified novel genetic and protein markers, which may represent additional indicators of patients with biologically aggressive, high-risk RCC (de Martino et al, 2012).
The recent progress in molecular biology has identified novel biological markers (Kohler et al, 1996; Risinger et al, 1998; Maxwell et al, 2001; Morrison et al, 2006) representing important alternative indicators of patients with biologically aggressive, high-risk tumours, which may benefit from adjuvant therapies to improve outcome (Greven et al, 2006; Randall et al, 2006).
Blood arsenic concentrations, a measure of biologically active arsenic, were between 0.2 and 24.1 μg/L, whereas hair arsenic concentrations, an indicator of cumulative exposure, were 1.1 724.4 ng/g.
