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The change in the FA composition may be regarded as an indicator of altered lipid metabolism occurring in vivo during human bladder tumorigenesis [84].
In advanced lung cancer, phase angle was speculated to be an indicator of altered tissue electrical properties [ 34].
Vacuolation has been shown as an indicator of altered acidification through a proton "trapping" mechanism [ 25] and inhibition of key lysosomal enzymes, including cathepsin D [ 30].
Professor Doré stressed that alternative stable states of gut microecology may be associated with immune-mediated disease conditions, and that reduced microbial diversity is a robust indicator of altered intestinal ecology and physiology.
These tiny RNA molecules, proven to be more stable than messenger RNAs [ 13], actively circulate in bodily fluids and, thus, are thought to represent a more direct indicator of altered physiology [ 14].
In this view of disease, alterations in Aβ expression would only be a part player in pathology or, perhaps even, a by-product, and an indicator of altered APP function and cleavage.
Similar(49)
However, the severe root growth defect observed in exocyst mutants could not be convincingly associated with any of several indirect indicators of altered auxin transport or signaling.
Indicator elements of altered wall rocks such as K, Al, As, Sb, and Hg have been successfully used to assess gold anomalies in lithogeochemical survey.
From this list of differentially expressed genes, we identified significantly enriched GO terms (FDR < 0.01), which serve as indicators of significantly altered biological processes during watermelon fruit development (Additional file 4).
The overall number of altered genes is a very good indicator of the level of cellular disturbance induced by a toxic compound.
An indicator of change.
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