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BSI can be used as a response indicator in prostate cancer patients, but further studies are needed to confirm the results of this retrospective study.
These results are in agreement with those of Dennis et al., who demonstrated the prognostic value of BSI as a response indicator in prostate cancer patients [11].
Thus, while lymphadenopathy is an independent adverse prognostic indicator in prostate cancer, clinical sequelae from lymphadenopathy are relatively uncommon.
Accordingly, MSMB expression has previously been reported to be a positive prognostic indicator in prostate cancer [ 29], although both these studies measured total, not isoform-specific expression levels.
The recent identification of the IGS as a prognostic indicator in prostate cancer and the correlation with its presence in a subset of the LNCaP cell line, suggest that CD44+CD24− LNCaP cells can serve as a model system.
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These data provide the first detailed descriptions of the stromal vs epithelial origin of the expression of the proteases and inhibitors, and indicate that several proteolysis-associated genes may be useful prognostic indicators in prostate cancer.
Several studies have demonstrated that ETS family gene re-arrangements are linked to clinicopathological indicators in prostate cancer.
Multivariate analysis suggests that EGFR and p65 are two independent prognostic indicators in prostate cancer tissue, which also supports previous reports analysing these two markers separately.
To date, some examples from recent studies are available: for example, lower level of H4K12-Ac is an indicator of recurrence in prostate cancer (Seligson et al. 2005) and increased H3K4 dimethylation and H3K18 acetylation activation mark correlated with poor prostate cancer prognosis (Schulz and Hoffmann 2009a).
Patient satisfaction, which is often assessed by heath care organizations, may be viewed as a useful, if imprecise, indicator of prognosis in prostate cancer patients, whether that association be due to improved general health, more positive emotions, or a combination of these.
Our hypothesis was that measurement of Ki-67 in such a well-defined cohort could provide prognostic information that supplemented the currently known indicators of prognosis in prostate cancer.
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Justyna Jupowicz-Kozak
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