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It has been reported that decreased p27 protein level is a negative prognostic indicator in human tumours including bladder cancer.
We also demonstrated a statistically significant correlation with ERb status which is a favourable prognostic indicator in human breast cancer.
Our findings demonstrate that this gene may have a tumour suppressor function and its mRNA expression could play a role as a prognostic indicator in human breast cancer.
As a single marker, CD44 is currently considered as a putative CSC indicator in human carcinomas including cancer of the lung.
The assessment of circulating Tregs or Tregs infiltrating the tumor itself has been used as a prognostic indicator in human cancers but conflicting results were obtained in different tumor diseases.
The LOXL2 protein has also been described as a poor prognosis indicator in human squamous cell carcinomas [ 121] and as a contributor to tumor cell invasion and metastasis during gastric carcinoma progression [ 122].
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ZEB1 is required for adipogenesis in vivo in mouse and its expression levels correlate with adipogenic indicators in humans.
Furthermore, the expression of these stem cell markers has been shown to be a poor prognostic indicator in several human cancer types [ 24, 26- 30].
Conclusions: The cross-correlation between fetal cardiac and somatic activity is an indicator of neuroregulation in human fetuses.
In conclusion, our results highlight intratumor CE accumulation as a potential indicator of proliferation in human breast cancer.
A higher male birth ratio is considered a sensitive indicator of health in human reproduction (Campbell 2001; Davis et al. 1998; Vartiainen et al. 1999).
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