Beyond the physical indicators, however, the relationship is deteriorating.
In many key indicators, however, the gap increased by 2012.
For the composite indicators, however, the reliability was good across all practices (>0.8, appendix 1), suggesting that comparisons between all practices should focus on the composite indicators.
For several indicators, however, the required sample size was considerably larger given that the expected amount of change (in percentage points) was lower.
It is known that going beyond measuring simple routines requires more complex indicators, however, the greater the complexity of the indicators used, the greater the difficulties of interpretation involved [ 35, 36].
If these risks can be managed by judicious use of the indicators, however, the potential to use routinely collected data for quality improvement will be enhanced for the benefit of patients.
In our study, marker positivity in BM had no statistically significant association with any of the traditional prognostic indicators, however, the results of mam and PIP gene expression in PBL had statistically significant association with the mam and PIP gene expression in BM (p = 2.5E-04 and p = 0.0188, respectively; Table 4).
A control group was not allocated because of ethical considerations, so it is not possible to prove a causal relationship between the interventions and changes in the six measured outcome indicators; however, the control of potential confounders by multivariate statistics provided reliable findings.
Antibody response is a poor indicator, however, because the various types of mycobacteria share antigens, and other infections raise similar antibody responses.
Our results suggest that tumours can spread directly through the blood-vascular system from their initial growth sites, and that lymph-node status was still considered a powerful prognostic indicator; however, biologically the combination of AMC and BVI is more significant than lymph-node status for tumour haematogenous dissemination.
