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Cyp26a1 regulates the cellular concentrations of RA via oxidation and its expression levels are used as a sensitive indicator for tissue RA concentration [ 28].
An F-statistic was computed at each probe from the smoothed M values to identify differential expression by tissue type (statistical model: M ijk = α i + ∑ k β ik X jk + ϵ ijk for probe i, biological replicate j, and tissue type k where X is an indicator for tissue type, compared to the intercept only model: M ij = α i + ϵ ij ).
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Considering solely the classical indicators for tissue damage, the results can be regarded as an indication that the A. blazei extract is able to provide a reasonable degree of protection against the paracetamol injury in both the hepatic and brain tissues.
Combined with the panel of potential cardiac injury markers, these results suggest a plasma-based series of metabolic indicators for tissue damage induced by heat stress.
In the following sections, the action of A. blazei will be discussed in terms of both the classical indicators for tissue damage as well as in terms of the functional and metabolic parameters.
If one considers only the classical indicators for tissue damage, the results that were obtained in the present study can be regarded as a positive indication that the A. blazei extract is able to provide a reasonable degree of protection against the paracetamol injury in both the hepatic and brain tissues.
Fluorescent dyes are promising for intracellular pH measurement [ 22], and since the ratio 620/634 is correlated to the pH, this method could give a new in vivo pH-sensitive indicator for tumor tissues.
Blood samples were obtained to measure EAA levels, inflammatory markers (procalcitonin, C-reactive protein and white blood cells), serum lactate level as an indicator of tissue hypoxia, and for blood culture.
Urinary bladder ΔPCO2 may be a useful indicator of tissue perfusion, but intestinal ΔPCO2 is the more sensitive carbon dioxide gradient for the monitoring of low flow states.
d Pain Pressure Threshold (PPT) indicator of tissue sensitization.
For the implantable tissue replacement methods, shear strength of the interface is very crucial indicator of tissue fusion [ 85].
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