For electrochemical detection, [Ru(NH3 6]3+ was added to assembled HCR concatemers, bound via electrostatic interactions with the negatively charged phosphate backbone of DNA, and could then serve as a redox indicator for electrochemical signaling.
We have consequently assessed the relevance of altered serum concentrations of COMP, as a tool for demonstrating activity in the joint and to determine whether this could indeed be used as an indicator to signal risk for progressive joint destruction in RA.
While previous studies have focussed upon the importance of the relative abundance of iron, we hypothesized that the specific iron source available may represent a niche indicator, signalling for the expression of genes important for adaptation and survival in the different microenvironments within the host.
The initial results have shown the applicability of such system for used as an indicator of signal disturbance from cellular phones.
Economic indicators have signaled for several months that the Fed's 14-month policy of raising interest rates to cool the economy and ease inflationary pressures has been successful.
Interestingly, the knockdown of FZD7 induced a significant increase of TopFlash activity, which acts as an indicator for increased canonical Wnt signalling.
To provide further supportive evidence for the role of Wnt signaling in the maintenance of prostate epithelial progenitors, we performed quantitative RT-PCR using Axin2 as an indicator for activation of Wnt signaling with prostate tissue prepared at various time points of development.
[Ru phen 3]2+ was selected as a redox indicator for amplifying electrochemical signal significantly.
In this manuscript, a transition indicator for non-stationary signals is presented.
As an immunohistological indicator for TGF-beta signaling, we made use of antibodies specific for the phospho-form of Smad2 (pSmad2) (Kandasamy et al., 2010).
Although all cells may not have apparent nuclear localization by IHC it is known that cytoplasmic accumulation of β-catenin is also an indicator for activated Wnt/β-catenin signalling and can predict survival outcome (Geyer et al, 2011; Khramtsov et al, 2010; Lugli et al, 2007; Martensson et al, 2007; Wong et al, 2003; Supporting Information Fig S8).
