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Phosphorylation of RPS6 and RB was used as long-term indicator for proliferation, cell cycle or tumour progression [ 28].
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Nuclear localization of Bcl-3 has been reported as an indicator for cell proliferation in different types of cancer [ 13, 15, 20].
Thymidine is one of the elements present in the DNA, and its incorporation into cells is known as an indicator for cellular proliferation.
The MTT colorimetric assay is often used as a first-line test for biocompatibility with a dual purpose of quantifying the cytotoxic effect of the scaffold materials towards the cells as well as an indicator for the proliferation rate of the cells [ 30].
Further confirmation of the miR-193a's role in Pa resistance of BCa came from the immuno-histological analysis of SRSF2 (a miR-193a-3p miR-193a-3p miR-193a-3ps target) and Ki67 (an indicator for cell proliferation) in the tumor sessions of the Pa-treated versus PBS-treated mice.
In contrast, nicotine did not affect colony density (Figure 2B, left panel) or the number of cells per colony (Figure 2B, right panel) which are indicators for cell proliferation.
Colony formation, as an indicator of proliferation ability, was completely inhibited by AgNPs at concentrations higher than 1 μg/ml.
The increase in the microbial count and the variation in pH, chemical oxygen demand (COD) and biological oxygen demand (BOD) were monitored and quantified as an indicator for growth and proliferation of microorganisms along the degradation of the selected PAHs in the mineral medium.
Our study revealed RRM2 was not only an indicator for breast cancers' proliferation and invasiveness, but also a biomarker for undifferentiation and stem/progenitor-like phenotypes.
Tumor incidence and size are indicators of proliferation and angiogenesis [ 31].
Defenses can strengthen deterrence by reducing the incentive for proliferation.
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