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Alterations of these genes may occur as an early event in the development of cancer, and their association with metastasis is not confirmed [ 45] even though one very recent study indicated that FEZ1 may serve as a novel prognostic indicator for lung cancer [ 46].
Thus, CypA shows promise as a novel therapeutic target and/or prognostic indicator for lung cancer.
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In HCC, CXCR7 and alpha fetoprotein levels were described as valuable prognostic indicators for lung metastasis and poor prognosis.
In accordance with these findings and based on existing literature [ 19, 26- 29] we developed a set of indicators for lung specialists to improve the identification of patients hospitalized for an AECOPD for whom proactive palliative care might be beneficial.
The indicators for lung injury and inflammation measured in BALF 2 hr after the 2-hr exposure to air or 2 or 5 ppm O3 are presented in Table 1.
Recently, BALF RAGE was considered a sensitive indicator for direct lung injury in acid or LPS-induced ALI in mice, particularly in acid-challenged mice [ 7].
The study identified a list of 25 potential indicators each for lung cancer and colorectal cancer, which will provide a guide to the design of web-based data collection forms to be completed by GPs participating in the main CANDID study.
The model performance indicators for each lung response category indicated that the model had better predictive capability for direct measures of inflammation (e.g., cell count, histopathology) than for indirect indicators (e.g., MIP-2).
We therefore interpret the classification of lung contusion as a reasonably good indicator for severity of lung contusion in the population investigated.
Bleomycin treated mice had increased BAL protein concentration, an indicator of lung vascular permeability.
The Charlson Index has also been validated as a prognostic indicator for survival in lung cancer cohorts.
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