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HOMA-IR, an indicator for insulin resistance, was also effectively decreased by LNA-miR-146b administration.
Plasma C-peptide, a part of preproinsulin peptide and therefore secreted in equimolar amounts as insulin by β-cell, acts as an indicator for insulin secretion.
We also did not find any association between the Ser1369Ala variant and fasting plasma insulin level or HOMA-B, an indicator for insulin secretion, either at baseline or after gliclazide treatment.
Our results add further support to the notion that the TG/HDL-C ratio may be a clinically simple and useful indicator for insulin resistance among nondiabetic adults regardless of race/ethnicity.
Although BMI, a less expensive and convenient measure, may serve as an indicator for insulin resistance among people with excessive weight, an elevation in the TG/HDL-C ratio could be a novel marker for hyperinsulinemia among people with normal weight in routine clinical practice.
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The recently developed HOMA-AD was a more accurate indicator for assessing insulin resistance than the HOMA-IR [ 64].
To assess whether betatrophin had an impact on β-cells in humans, we used C-peptide as an indicator for endogenous insulin production.
Assuming that simulated insulin binding to the receptor mirrors physiological processes well (we show below that it does), receptor internalization can be used as a direct indicator for hepatic insulin degradation.
Particularly relevant are the differences for resistin (an indicator of insulin resistance) and PS (an indicator of apoptosis).
Model 3 was additionally adjusted for TG/HDL-C (which was a good indicator of insulin resistance).
Other treatment use during the baseline and follow-up period were characterized by major drug groups for T2DM, including drug class-level indicators for metformin, insulin, sulfonylureas, thiazolidinediones, DPP-4 inhibitors, and other miscellaneous diabetes drugs.
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