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The time interval between the first incidence of any indicator code group or keyword and the first coded diagnosis of RA was calculated.
This was indicated in the database using categorical dummy variable for each indicator code group.
We identified inpatient and SNF claims for FFS datasets using the short stay/long stay/SNF indicator code variable included in the MedPAR dataset.
The code in File S1 allows the user to make more specific plots than the ones we present, e.g., maps for each separate indicator (code S1, "NI commands.R" file, section 7.2), comparisons of interpolated and non-interpolated maps (section 7.5), or maps comparing changes over time with their associated p-values (section 7.7).
Forty-nine (3%) patients had an infection indicator code during initial hospitalizations.
There were no gender differences in the prevalence of indicator code groups or keywords.
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Interview notes were transcribed, and risk events were identified and coded using a set of risk indicator codes.
Of all analyzed indicator coded SNPs of the FADS1 FADS2 gene cluster none showed a statistically significant association with the dichotomous outcome parental reported eczema in the first 2 years of life (Table 3) in both unadjusted and adjusted analyses (see methods).
The intervals between keywords and RA code were similar to intervals between the indicator codes and RA code.
We reviewed full text medical records of patients with indicator codes to confirm infection status.
Indicator coding was used for categorical predictor variables, with the first category in each group treated as the reference group.
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