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Using a transgenic zebrafish line with a fluorescent cell cycle indicator, a large chemical screen identified several small molecules along the Hedgehog, insulin-like growth factor and transforming growth factor-β signaling pathways that modulate cardiomyocyte proliferation during regeneration (Choi et al., 2013).
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If the choice of policy is sensitive to the precise value of the indicator, then an indicator with a large concealed uncertainty may be worse than none at all.
Unfortunately, we could not collect data about such indicator over a large enough period of time.
Of those suggested, only time to antibiotic treatment has been evaluated as a quality indicator in a large US study.
Because of the anatomy of the cerebral circulation, SjO2 is an average indicator and a large volume of brain must be underperfused for an abnormality to be detected.
Similarly, liver invasion has evolved as an independent survival indicator in a large prospective study involving 539 patients with advanced gastric cancer that had undergone surgical resection [ 18].
Another indicator is a large angle between the estimates of the m-th eigenvector from the two analyses (the dot product of two normalised vectors gives the cosine of the angle between them): if one of the analyses picked up the wrong direction, this is expected to be orthogonal to the true direction, i.e. we expect it to be close to 90°; see Meyer and Kirkpatrick [ 49] for details.
Items were deleted when they had significantly lower item reliability than that of the other items posited to measure the underlying construct, showed insignificant path coefficients for the construct, showed large residuals with other indicators, shared a large amount of variance with other indicators, or shared common variance with indicators posited to measure other constructs.
For each LSA indicator, higher scores indicate a larger life-space.
Spatial location should be an accurate exposure indicator, a sufficiently large population should be included to generate precise estimates of rare health events such as birth defects or childhood cancers that are often of concern, and information on the associated characteristics of the exposed population, that is, confounders, needs to be available.
But the 21m hits on his MySpace – and 1m Stateside downloads of his single Best I Ever Had – are strong indicators of a large, and broad, appeal.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com