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This trend was also confirmed by analysis of differentially expressed genes for indicative over- and underrepresented gene ontology categories (GO terms).
The condition number was 250, which is reasonable and not indicative of over-parameterization.
This was not the case when more features were added, indicative of over-training in leave-one-stent-out.
In addition, the drop in OFV (−4.2) was only borderline significant, and resulted in a model with a condition number exceeding 2500, which is indicative of over-parameterization.
We investigated whether the genes with small counts were those with the smallest (indicative of over-fitting) or largest (indicative of under-fitting, or not explaining enough variation) GOF statistics when using NB distributional assumptions with local variance estimate and no blocking factors.
Unlike the other algorithms that solely provide SNV calling capability, Strelka has its own inbuilt post-calling filter for sites with extremely high depth indicative of over-mapping to repetitive sequences; reads with too many mismatches to the reference; and the presence of spanning deletions mapped across the site.
Danny Gabay, of Fathom Consulting, says the reaction of markets last week to the statement of G20 finance ministers in St Andrews was indicative of the over-optimistic mood.
Altruism as a motivator could be indicative of an over-representation of relatively healthy and highly educated people in the research setting.
The increase of IL-6 and TNFα serum levels is indicative of an over-all proinflammatory state that develops during the aging process.
Finally, comparison between incursion detections (both virus and vector) and predictions by the model of the possible frequency of such events are indicative of an "over-prediction" of events by the model.
CES was identified by gain-of-function phenotypes of the ces-D mutant: drastic morphological changes indicative of BR over-accumulation/BR hyper-responses that correlated with elevated levels of DWF4, CPD and ROT3 mRNAs and increased amounts of late BR biosynthesis intermediates 6-DeoxoCS and CS.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com