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A transient elevation of thiobarbituric acid reactive substances indicative of lipid peroxidation present in the brain was observed after the SWCNT exposure [138].
Finally, we measured the levels of malondialdehyde (MDA), which are indicative of lipid peroxidation as a marker of oxidative stress.
H&E stained liver sections were also compared between groups for the amount of unstained intracellular space within hepatocytes, indicative of lipid accumulation.
Both ADFP and ACSL1 are indicative of lipid accumulation through either sequestration or de novo synthesis.
Such positive correlations, indicative of lipid coregulation, occurred both within and between lipid classes.
Anthropometric measurements indicative of lipid redistribution, such as skinfolds, hip and waist circumference, could be useful to document such manifestation.
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In addition, the close association between CRAT and the genes involved in lipogenesis reinforces the relationship between lipogenesis and β-oxidation, thus being indicative of high lipid turnover in those animals with high lipid deposition.
Previous observations of decreased fat pad mass and respiratory quotient at an early stage in SOD1G86R mice (Dupuis et al, 2004) and increased lipid clearance in these mice (Fergani et al, 2007) are indicative of increased lipid use.
Attenuation indicates the density of muscle with lower attenuation indicative of greater lipid infiltration [ 15].
Consistent with this, 0.5 mM BEZ treatment of AML cell lines labelled with the naturally fluorescent lipid cis-parinaric acid was associated with a significant decrease in fluorescence, indicative of increased lipid peroxidation (Figure 6A).
However, from 5 days of age onward the LUN mice simply had smaller adipocytes indicative of reduced lipid accumulation (data not shown).
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