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In total, we characterized 5 conditions as indicative of impairment (visual, hearing, cognitive, mobility impairment and urinary incontinence).
These vacuole-like vesicles resembled those found in a patient with mutation in dynamin-2 gene (Karolczak et al. 2014), indicative of impairment of endocytic vesicle processing.
Instead, they became oval with centrally located nuclei in a nest-like structure, indicative of impairment in the nuclei positioning and/or cytoskeleton organization.
Thus, these results emphasize that low scores do not necessarily need to be indicative of impairment, but may also represent normal variability of cognitive abilities within healthy adults.
These data suggest that TA muscle fibers from mouse models of SMA are not undergoing degeneration, but rather that the increase in central nucleation observed is indicative of impairment in muscle development.
Behavioral analysis of the mutant mice revealed an array of discernible abnormalities, including impaired motor coordination, aberrant social behavior, excessive self-grooming, and reduced freezing during contextual and cued fear conditioning, indicative of impairment in emotional learning and memory.
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Muscle lipid use was significantly lower in prediabetic and diabetic muscle, indicative of impairments in lipid oxidation.
Although the reduction of NAA levels is a condition that may occur also in other neurodegenerative diseases, this finding in PD patients may be indicative of impairments in mitochondrial metabolic system that hypothetically contribute to neuronal degeneration.
It has therefore been generally believed that the exhausted phenotype would be indicative of functional impairment, while the current study actually analyzed for and detected functional impairment, specifically in the CD4+ T cells as a potentially earliest biomarker for disease progression.
At THC concentrations >30 ng/ml the proportion of observations indicative of significant impairment increased to a full 100% in every performance tests.
At concentrations between 5 and 10 ng/ml approximately 75 90% of the observations were indicative of significant impairment in every performance test.
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CEO of Professional Science Editing for Scientists @ prosciediting.com