If the genes that do have a particular binding site are over-represented in the group, this is viewed [31] as indicative of functionality of the corresponding BSs.
The cluster is conserved in all mycobacteria, corynebacteria, nocardia, and rhodococci with available annotated databases, indicative of functionality common to actinomycetes.
A significant deviation of an oligo density in the proximity of SSs as compare to background locations is strongly indicative of important functionality of elements related to splicing [ 10, 15, 33].
Nonetheless, insulin-stimulated induction of p-AKT (Fig. 3 F ) and [H]glucose uptake into explants (Fig. 3 G ) were significantly higher in 6 mo LFD adipose compared with 6 mo HFD, indicative of preserved functionality.
These cocultured neurons were then stained for synapsin I as a measure of presynaptic differentiation, which has been associated with the positive uptake of synaptotagmin luminal domain antibodies, indicative of its functionality (Mah et al., 2010).
Interestingly, evidence for directional selection is found in several gene families underlying both adaptive and innate immune systems in Atlantic cod through expansions of genes for MHC I and Toll-like receptors (TLRs) 3, indicative of enhanced functionality for these systems (Fig. 1).
While we are unable to find a dif sequence corresponding to the XerS machinery, xerS gene in this species is located close to the GC skew shift-point (xerC: 1031814-bp, xerD: 1055574-bp, xerS: 1228715-bp, and GC skew shift-point: 1225733-bp), which is indicative of its functionality as shown in previous works [ 25, 26, 46].
Efforts to study functionality have mostly consisted either of the detailed characterization of individual lncRNAs or surveys of large sets of lncRNAs to search for evolutionary signals indicative of function.
Focusing on between tissue comparisons, we found that in four cases (cdc42, ncoa3, pik3r1, and ar), the overexpression of the A or B duplicate changed depending on the tissue type, again indicative of different functionalities of the gene copies.
In several cases, the slit-lamp appearance may not be indicative of the bleb functionality because the clinical analysis is a qualitative assessment affected by the intra- and interobservers variability.
There are clear differences between IS types in terms of functionality and sequence divergence, which are indicative of different stages of IS degeneration.
