Sentence examples for indicative of dysfunctional from inspiring English sources

In contrast to the findings of this study, a few CPM studies in TMD and OA patients have shown impaired CPM effects indicative of dysfunctional endogenous analgesic systems [27, 29].

The elevated activity of the autophagy lysosome pathway is indicative of dysfunctional mitochondria [ 44].

Furthermore, this group identifies two tumours with a low RAD51 score, indicative of dysfunctional HRR, in fresh tumour tissues from 13 patients with NSCLC (Birkelbach et al, 2013).

Thus, the blunted CAR found in our study is indicative of dysfunctional HPA axis in PSD patients and may be related to the emotional or physical distress and PSD-associated symptoms such as fatigue, vegetative symptoms (e.g., disturbances in sleep, appetite, sexual drive, or energy metabolism), or depressive mood.

As expected, depletion of Mps1 prevented cells from accumulating in mitosis upon nocodazole treatment, indicative of a dysfunctional mitotic checkpoint, and caused defects in chromosome alignment.

Together, our data imply that antigen-primed CD8+CD44hi T cells infiltrating SCC FAK-WT tumors exhibit a heightened state of exhaustion indicative of a dysfunctional T cell response.

The changes in expression of Grxcr1 in Ptprq-CAT-KO homozygotes, and of Otof in both diminuendo and Ptprq-CAT-KO homozygotes, may be only indicative of a dysfunctional hair cell.

Evaluation of pharmacological sensitivity in breast cancer cell lines representing all breast cancer subtypes suggests the BD-L signature may serve as a biomarker to identify sporadic breast cancer patients who might benefit from a therapeutic combination of PARP inhibitor and temozolomide and may be indicative of a dysfunctional BRCA1-associated pathway.

Except in one case (patient 7, Table 4), staining was in concordance with the combined results of the p53 staining and LOH of chromosome 17p results published previously by Middeldorp et al (Table 4).[ 13] When staining was indicative of a dysfunctional p53 status, a mutation as well as LOH was found (patients 2, 23, 24, and 41).

Skin alterations are an indicator of dysfunctional housing.

Cells with a decreased fluorescence of JC-1 aggregates (590 nm), indicative of decreased membrane potential (and dysfunctional mitochondria), accumulated in cultures exposed to IGF-I beginning at 7 10 days in culture up to the maximum time examined, at 14 days (Fig 2).