In addition, DRI values for both the cytochalasins and currently approved agents were indicative of favorable dose reductions, although this would be expected from the isobolograms.
This finding could be considered as indicative of the dose-response relationship of tumor induction and could be used in risk assessment.
Given equal experimental conditions, the temperature increase is indicative of the PEF dose, and a more uniform temperature profile is thus indicative of a more homogeneous PEF treatment.
Odds ratios were higher among people with characteristics indicative of a higher dose of ultraviolet light (sun sensitive phenotype) and to some extent with histological evidence of actinic keratoses.
Third, considering the type B virus component of the Fluvax 2008®, we see Nanopatch™ delivery of low doses of HA induced substantial HI activity above the critical value of 1∶40 at 3 weeks, again indicative of protection at doses as low as 34 ng compared to 6000 ng with intramuscular injection.
However, the pattern of expression was similar to a hormetic inverted U-shaped dose response curve, indicative of a low-dose stimulation (Cook and Calabrese, 2006).
It was observed that the production of Hepatitis-A antigen was almost two-fold higher in iCELLis Nano bioreactor system as compared to the other two systems indicative of higher number of doses in iCELLis Nano system (Figure 1).
The team addressed and deleted extreme outliers in dosing (e.g., clinically implausible doses indicative of data entry errors).
A lower incidence of dose delay, indicative of less toxicity, was seen in carriers of the SLC22A16 A146G, T312C, T755C variants.
Engineered (spray dried) powder formulations were associated with relatively high TLD (> 50% of nominal dose) compared to lactose blend and agglomerate based formulations, which had a lower TLD (7 40% of nominal dose), indicative of less efficient targeting of the lung.
