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These melanomas responded initially to PLX4032 but relapsed after various progression-free durations, indicative of development of acquired resistance.
On the other hand, durations of responses are commonly limited with most patients relapsing within 1 year, indicative of development of acquired drug resistance.
All miR-142 recipients had reduced LV ejection fraction, fractional shortening and increased systolic and diastolic dimensions relative to their non-targeting-injected, genotype-matched controls (Fig 7A C and Table III of Supporting Information), indicative of development or worsening of heart failure.
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In some aspects of the evaluation, we identified small increases in understanding and capability development between 3 and 12 months post-intervention, indicative of ongoing development beyond the intervention period.
Overall, auxins seem to be shutting down normal growth patterns in older seedlings and initiating non-specific tissue growth that is more indicative of early development and/or vegetative propagation.
Ferocity of competitiveness among rival poets is neither telling nor tension-producing in this piece, merely indicative of arrested development.
The growth of the "legitimate" theatre from the 1880s, in distinction to more popular, melodramatic forms, is indicative of this development.
If this pattern is indicative of knowledge development, it should also correlate with path efficiency gains during later trials.
The reporting of subclinical AVN in the later series [16, 42] using MRI is indicative of this development.
Fresh 0.075 wt% NaBH4 was then added drop wise until the solution turned a red wine color (indicative of seed development), followed by stirring for five additional minutes.
Levels of blood urea nitrogen and creatinine were increased in wild-type and IL-17A−/− mice with CLP-induced sepsis compared with those in the sham group, indicative of the development of SA-AKI.
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