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The results can be as strongly indicative of breast cancer risk as a mutation in the BRCA gene, but those odds will apply to many more women.
Hence, SCCA expression may be indicative of breast SCC and has the potential to be a valuable marker of breast SCC, as well as predicting disease severity and response to treatment as has been demonstrated in other SCCs.
Retesting after 14 months now revealed a 64kDaa pH 5.1 transcript variant indicative of breast cancer.
A sensitivity analysis was performed by evaluating breast cancer rates in the post-period in patients without a code indicative of breast cancer in the pre-period.
We have performed feature-selection and classification techniques to identify blood serum proteins that are indicative of breast cancer in premenopausal women.
The fact that the signature is indicative of breast cancer mortality would support the view that subtle epigenetic mis-programming of immune cells may lead to general immune defects which in turn supports the development and proliferation of cancers.
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Wt1 presents a developmental pattern of expression in normal mammary gland, and changes observed in cell lines and tumors may be indicative of breast-tumor-related perturbations of Wt1 expression [ 29].
Factors that may be indicative of hereditary breast cancer are young age at diagnosis, multiple family members with breast cancer, male relatives with breast cancer, breast and ovarian cancer in the family and/or breast cancer and prostate cancer in family members at a relatively young age.
It would also be useful to confirm the findings of a study [ 47] that reported that perinatal characteristics indicative of high breast cancer risk predict mammographic patterns that are associated with high breast cancer risk in adult life.
We used PAM analysis and identified 30 genes that were indicative of IHC breast cancer subtype that segregate the pathology-defined subtypes in an unsupervised hierarchical analysis.
Assuming levels of methylation of ESR1 < 0.02 relative units, "test of methylation ", was indicative of absence of the disease (physiological) while levels of methylation of ESR1 > 0.02 relative units measured in the plasma "test of methylation " was indicative of presence of breast cancer (pathological level of methylation).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com