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It is indicative of a defect system distributed in a dilute manner with negligible defect clustering.
If I am injured by the failure of the other to conform to an idea that I had of her, this is not indicative of a defect in the other; it is the result of my inappropriate attempt to determine her by insisting that she conform to my idea.
Such profiles are indicative of a defect in sustaining FA disassembly.
Similar to the constitutive silencing of PHB1 or PHB2, induction of shRNA expression reduced the proliferation of cells and prevented colony formation on soft agar plates, indicative of a defect in anchorage-independent growth.
Interestingly, only ML240 induced accumulation of the lipidated LC3-II species, which is indicative of a defect in autophagosome maturation.
Similarly, PC-3 cells do not express detectable p53 and they exhibit microsatellite instability indicative of a defect in MMR [ 39, 40].
Similar(44)
In contrast, the pri2(C417A, C474A, C474A) mutant permanently arrested with a G1 DNA content after being released from G1 at 37°C, indicative of a severe defect in initiation of DNA replication.
Loss of PDK1 causes a size reduction of β-selected pre-T cells indicative of a metabolic defect (Hinton et al, 2004).
This phenotype is indicative of a differentiation defect and a similar lack of cortico-medullary definition is observed in kidneys homozygous for the Lp mutation in Vangl2 (9).
When both components are deleted, >65% of invaginations show retraction back toward the plane of the plasma membrane indicative of a scission defect [ 11].
In addition, the NMD target gene transcripts of Atf4, Gas5, Ddit3, and 1810032O08Rik were all up-regulated in knockdown ESC clones (Fig 6B), indicative of a NMD defect.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com